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Objectives: To conduct a systematic review and meta-analysis regarding the efficacy and safety of inhaled corticosteroids for COPD exacerbationsin adults with short or moderate airflow. Methods: MEDLINE were searched, and key titles and abstracts were reviewed, trt before and after. Abstracts published within the last 3 years were included. Results were extracted and cross checked by 2 independent reviewers to confirm the authors' conclusions, steroids-click review. Results: Fifteen studies were identified and included 1,829 participants. Among these studies: 3 studies (n=463) included the first time to determine risk reduction and 4 (n=569) involved the assessment of risk reduction after the first time to determine potential for an increase. Four studies of inhaled corticosteroids failed to find a significant risk reduction and 2 studies (n=1470) reported an increase, review steroids-click. Conclusions: We conducted a systematic review and meta-analysis of the clinical efficacy and safety of inhaled corticosteroids for COPD exacerbations. The use of inhaled corticosteroids should be discouraged in COPD exacerbations, side effects of anabolic steroids after stopping.
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